Merck Anti-CYBB antibody produced in rabbit
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Anti-CYBB antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody
Anti-CGD, Anti-GP91-1, Anti-NOX2, Anti-Cytochrome b-245, β polypeptide (chronic granulomatous disease), Anti-GP91-PHOX
CYBB (cytochrome b-245), belongs to the family of NADPH oxidases, that catalyze the generation of the superoxide ion. It is a six-transmembrane glycoprotein, that binds heme, flavin and NADPH. CYBB associates with membrane-bound p22phox to assemble the heavy subunit of flavocytochrome b558, the catalytic component of phagocyte NADPH oxidase. It also associates with four cytosolic components p47phox, p67phox, p40phox and Rac2 required for NADPH oxidase activity. Homologs of the NOX protein family include the catalytic subunits NOX1, NOX3-5, Duox1 and Duox2. NOX2/gp91phox is expressed in neutrophils and phagocytes.
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